Insulin has a variety of dosage forms, including short-acting, intermediate-acting and long-acting dosage forms. There are three options for treatment as follows:
The first regimen: short-acting insulin injection before meals, applicable for diabetes patients with moderate secretion of insulin, but insufficient secreted at meals. Short-acting insulin is characterized by fast absorption, short duration, achieve blood glucose control in a relatively short time, and convenient for dosage adjustment.
The second regimen: combined use of insulin and oral hypoglycemic agents: Subcutaneous injection of intermediate-acting insulins or long-acting insulin analogues before sleep, and oral administration of hypoglycemic agents during the day. This regimen is applicable for diabetes patients with partial islet function, so as to control fasting blood glucose well all night by using the intermediate-acting insulins or long-acting insulin analogues, and to maintain glucose levels through the use of oral administration of hypoglycemic agents during the day, so as to ensure good control of the whole day's blood glucose.
The third regimen: replacement therapy of insulin therapy, blood glucose is controlled mainly achieved by insulin throughout the day while stop the injection of all insulin secretagogues. Premixed insulin is injected before breakfast and before supper, respectively, short-acting insulin can be injected before each meal, combined with intermediate-acting and long-acting insulin before sleep. This treatment is mainly applied to the diabetes patients with complete failure of islet function and the failure of oral hypoglycemic agents.
It is important to note that short-acting, intermediate-acting and long-acting dosage forms insulin all cannot be used for intravenous injection, and can also not be used for emergency treatment of diabetic patients with acute complications such as ketoacidosis diabetic coma.
Insulin therapy should follow the principle of individualized medication. Corresponding treatment plan should be adopted according to each diabetes patient's disease type, disease condition, age, body weight, liver and kidney function, work and rest rules, economic conditions and so on.
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