Studies have confirmed that the wide fluctuations in blood pressure can not only can lead to cardio-cerebral vascular incident, but also cause injuries to the important target organs (Heart, brain, kidney, etc.) in patients with elevated blood pressure far more severe than those to vessels by elevated blood pressure. The reason is that the wide fluctuations in blood pressure can result in injuries to the arterial vascular endothelial cells (Such a result is often prelude to sclerosis of the arterial vessels) and activate the renin-angiotensin system (RAS) within bodies easily, and thus generating a series of adverse effects on human bodies. Besides, fluctuations in blood pressure may cause left ventricular hypertrophy easily and increased incidence of vascular remodeling, thereby inducing vascular inflammation and accelerating the apoptosis of cardiomyocytes. To sum up, not only effective lowering of blood pressure is stressed (blood pressure decreased to 140/90mmHg or less) in the antihypertensive therapy, but also stable lowering of blood pressure should be achieved.
For some people with high blood pressure, although they stick to the administration of antihypertensive drugs everyday, their blood pressure is not very stable. The reasons for this can be roughly classified into the following several points:
Taking drugs at random
When some patients hear people around them say that some antihypertensive drug shows good effects, they buy it immediately, and they rush to switch to other drugs when they feel uncomfortable.
Taking drugs blindly
Some people only know to take drugs on time while measure their blood pressure aperiodically. They go to hospital to measure their blood pressure even at an interval of half a year or longer, and they do not adjust their medication in time according to the rule of changes in their blood pressure.
Changing drugs frequently
Some patients eager to lower their blood pressure often hope to find the ideal antihypertensive drugs in the short term. They can not tolerate the mild adverse reactions of individual antihypertensive drugs or dislike the slow antihypertensive effects of some drug, and thus they change drugs frequently.
To measure their blood pressure regularly, and adjust the dosage of drugs or change the method of treatment according to the fluctuations of blood pressure.
To undergo dynamic monitoring of blood pressure once or twice a year (Once in summer and once in winter are recommended) to know the rule of changes in blood pressure in the whole day, thereby better arranging the time for medication and selecting the types of antihypertensive drugs.
To try to take long-acting antihypertensive drugs (such as controlled release pellets, sustained release tablets, etc.), which enables the drugs to be kept in a relatively stable concentration in the blood
and avoids the wide fluctuations in blood pressure.
Not to take many types of antihypertensive drugs at the same time to avoid the concentrated action of drugs, which may lead to unstable blood pressure.
To try to take ACEI (such as Capoten Tablets, Monopril, Lotensin, ect.), which is conducive to stable blood pressure and can avoid injuries to vascular endothelium.
To take different antihypertensive drugs at a small dose in combination, which can not only lower the blood pressure effectively, but also decrease the adverse reactions induced by various drugs.
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Necessary Tests and Examination for People with high blood pressure
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Systolic hypertension in elderly (SBP > 160 mmHg, DBP < 90 mmHg)
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Drugs for complications of hypertension in the elderly
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